Y.S.Rajasekhara Reddy was born on Eighth of July 1949 at Jammalamadugu Mission Hospital near pulivendula. His schooling was in Bellary. He graduated with a degree in medical science from Mahadevappa Rampure Medical College (MRMC),Gulbarga, Karnataka and completed his House surgeon at S.V. Medical College,Tirupati, Andhra Pradesh. He was the elected leader of the House Surgeon's Association at S.V. Medical College, Tirupati.

Dr Y.S.R was a natural heir to his father’s legacy. His father had always been a source of inspiration for YSR since his childhood. It was none other than Sri Raja Reddy who led YSR into active politics. If YSR had any role model in his earlier days it was his father. His brutal murder in 1998 inflicted a deep injury and left a dark scar on YSR’s heart. Dr. YSR practiced medicine for sometime in the District. The hospital was built by his father for him at Pulivendula is still running. The YS family has also built and ran a degree college and a Polytechnic College at Pulivendula, for a few years which was later handed over to the Loyola Group of Educational Instituitions.Another junior college at Simhadripuram, a small town in the vicinity of Pulivendula, is being run by YS family.

YSR is married to Smt. Vijayalakshmi in 1971 and is blessed with a son and a daughter. A proud-dad he is, YSR enjoys the company of his grand children to the brim- needless to mention here that he rarely finds any time to spare for his family members. His busy schedule hardly allows him to steal a few moments for his family. YSR’s son emerged a successful entrepreneur to the utmost pleasure of his father. Son Jagan Mohana Reddy, daughter Sharmila, and their children enjoy a very special place in YSR’s world.
Y.S. Rajashekar Reddy popularly known as YSR, was a two-time Chief Minister of the Indian state of Andhra Pradesh, serving from 2004 to 2009. He has been viewed as the most popular chief minister of Andhra Prades.
In the words of Yahoo 'YSR was a mass leader who ruled the hearts of people in Andhra Pradesh'.

The BBC called him a champion of social welfare schemes.

He was elected to the 9th, 10th, 11th, and 12th Lok Sabha from the Kadapa constituency for four terms and to the Andhra Pradesh Assembly for five terms from the Pulivendula constituency. His candidature won every election he contested. In 2003 he undertook a three-month-long paadayaatra, walking tour of 1475 km during the very hot summer months, across several districts in Andhra Pradesh as a part of his election campaign. He led his party to victory in the following general and assembly elections held in 2004. He repeated the feat in 2009.

Y. S. Rajasekhara Reddy's Bell 430 helicopter went missing on Wednesday, 2 September 2009 at 9:35 am. Begumpet and Shamshabad Air Traffic controllers lost contact with the aircraft at 10:02 am while it was passing through the dense Nallamala forest area. The Chief Secretary of Andhra Pradesh, P. Ramakanth Reddy, said that inclement weather had forced the helicopter off-course. Although the sparsely populated forest area is considered to be stronghold of the outlawed Naxal communist insurgents, the National Security Advisor of India ruled out the possibility of the Naxals bringing down the helicopter.

The Indian Prime Minister's Office confirmed the helicopter's crash on the morning of 3 September and the death of all aboard, including Reddy, his special secretary P. Subrahmanyam, chief security officer A. S. C. Wesley, Group Captain S. K. Bhatia and Captain M. S. Reddy. The Director General of Police said that the bodies of Reddy and others were charred beyond recognition and had to be identified on the basis of clothing. The autopsy of all the bodies was carried out at Kurnool Medical College.

An investigation eventually concluded that the factors that caused that crash included the fact that the crew became fixated for more than six minutes about a problem with their transmission oil pressure system, and were distracted from the worsening weather. It was also noted that the pilots of the helicopter never discussed the bad weather, diverting, or returning to base.

Y.S Rajashekar Reddy's body was buried on 4 September at Idupulapaya in Kadapa district with full state honors in accordance with Christian rites. Now so called Idupulapaya is named as Y.S.R Gath.

Mr Y.S Jagan is son of , Y.S.Rajashekar Reddy was a natural heir to his father’s legacy. His father had always been a source of inspiration. He was born in Pulivendula village of Kadapa District, Andhra Pradesh on December 21st, 1972. He received his early education from Pulivendula and Hyderabad Public School. He studied his M.B.A. degree. He started his political career by campaigning for Congress party in 2004 elections in Kadapa District, and in the 2009 elections he was elected as member of Parliament from Kadapa constituency as a member of the Indian National Congress. He was elected to the 15th Lok Sabha (Lower House) from the Kadapa (YSR district) Parliamentary constituency with huge majority. Jagan appointed as a Member of the Parliament's Standing Committee on Finance.

His political career took a new innings with the demise of his father and Chief minister Dr Y.S. Rajasekhara Reddy. Throughout his public life, Mr. Jagan has worked actively for the welfare of women and children and the underprivileged sections of society. For their benefit, he established several institutions.

However, his political career took a new innings with the demise of his father, Chief Minister Y.S. Rajasekhara Reddy ("YSR"). His relationship with the Indian National Congress (INC) continuously deteriorated after his father's death.

Six months after his father's death, he began an odarpu yatra (condolence tour) as promised earlier to go and meet the families of those alleged to have either committed suicide or suffered ill health on the news of his father's death. The Congress party's central leadership directed him to call off his odarpu yatra, and order which he defied leading to a fallout between the high command and himself. He went ahead with the yatra, stating that it was a personal matter.

On November 29, 2010, he resigned, after a fall out with the Congress party high command. He announced on 7 December 2010 from Pulivendula that he would be starting a new party within 45 days. In February, 2011, he took over a party which had existed on paper only since the prior July, and was officially recognized on February 16 as president of the YSR Congress Party. On March 12 he launched YUVAGANA SRAMIKA RYTHU (Y.S.R ) Party flag at Y.S.R Gath.